How are BDNF and Wechseljahre related?

BDNF (Brain-Derived Neurotrophic Factor) is crucial for neuroplasticity and neuronal survival. During menopause, declining estrogen levels can affect BDNF expression. Some studies suggest a link between low BDNF and menopausal cognitive complaints or mood changes. However, evidence is still limited; most genetic variants in BDNF have small effects and are not clinically predictive. A blood test for BDNF protein levels would be more informative than a DNA test. Caveat: No validated genetic recommendations for menopause management; lifestyle and hormonal factors play a larger role.