Myths vs facts: CLOCK and Langlebigkeit

The CLOCK gene family regulates circadian rhythms. A common myth is that specific CLOCK variants directly determine lifespan. Fact: Polymorphisms like rs1801260 are linked to sleep-wake patterns, but their effect on longevity is indirect and small. Studies show associations with metabolic disorders, not extended maximum lifespan. Evidence is mostly mechanistic (animal models) and GWAS-based, with inconsistent human results. A DNA test for CLOCK variants cannot predict individual longevity. The influence of lifestyle (light exposure, sleep hygiene) is far greater. Beware of marketing that turns weak associations into 'longevity genes'. Clinical utility is currently minimal.