What role does BDNF play in Langlebigkeit?

BDNF (Brain-Derived Neurotrophic Factor) is a protein that supports neuronal survival and plays a key role in neuroplasticity, learning, and memory. In the context of longevity, BDNF is often linked to improved cognitive reserve and reduced risk of age-related neurodegenerative diseases like Alzheimer's. Animal studies show that elevated BDNF levels can extend lifespan by enhancing mitochondrial function, stress resistance, and autophagy. In humans, evidence is largely associative: higher BDNF levels correlate with better cognitive performance in aging and lower dementia risk. The Val66Met polymorphism (rs6265) impairs BDNF secretion and is associated with accelerated cognitive decline. However, BDNF is not a direct 'longevity marker' for lifespan extension; effects are modest and heavily influenced by lifestyle factors such as exercise, caloric restriction, and sleep. Commercial DNA tests that market BDNF variants as 'longevity genes' often overstate clinical relevance. Genetic prediction of longevity alone is not feasible. Conclusion: BDNF is important for healthy aging but not a reliable predictor of maximum lifespan.