welche werte bei schilddrüsenunterfunktion — can a DNA test help?

Hypothyroidism is diagnosed via blood tests: elevated TSH, low free T4, and optionally free T3 and thyroid antibodies (TPO, Tg) to identify autoimmune causes like Hashimoto's. A DNA test cannot replace these lab values. While certain genetic variants (e.g., in HLA, CTLA4, PTPN22) are associated with increased risk of autoimmune thyroid disease, they lack sufficient predictive power for individual disease onset, severity, or treatment response. Clinical management relies on blood markers and symptoms, not genetics. Therefore, a DNA test does not help diagnose or manage hypothyroidism. Evidence: human-moderate for risk associations, but practice for clinical utility. Safety note: Do not self-medicate with thyroid hormones without medical supervision.