What to watch with Testosteron and menopause?

During menopause, women's testosterone levels naturally decline, potentially contributing to low libido, fatigue, and reduced bone density. Testosterone therapy is sometimes considered, but evidence is moderate and long-term safety not fully established. Key monitoring includes total and free testosterone, SHBG, and possibly genetic variants in SHBG (rs1799941) or androgen receptor (CAG repeat) that may modulate response. Watch for side effects like hirsutism, acne, voice changes, and cardiovascular risks. Therapy should only be under medical supervision with regular follow-up. Evidence: human-moderate. Caveat: not a routine recommendation; individual risk-benefit assessment required.