Is MTHFR useful for Langlebigkeit?

Whether MTHFR is useful for longevity requires a nuanced answer. MTHFR encodes an enzyme in folate metabolism and influences homocysteine levels. Elevated homocysteine is a risk factor for cardiovascular disease, which can affect lifespan. However, direct evidence linking MTHFR variants (e.g., C677T) to longevity is weak. Most studies show no robust association with maximum lifespan, only modest links to cardiovascular risk. Moreover, MTHFR is often overhyped in direct-to-consumer genetic tests. Stronger longevity markers include FOXO3 (rs2802292) and APOE. Thus, MTHFR alone is not a reliable indicator of longevity. Adequate folate intake is advisable for everyone regardless of genotype. The clinical utility of MTHFR testing remains controversial; it should not be the sole basis for lifestyle changes.