The CLOCK gene is a core component of the circadian clock. Circadian disruption is linked to aging processes such as oxidative stress, inflammation, and metabolic decline. However, direct evidence that specific CLOCK variants meaningfully predict human longevity is limited. Most findings come from animal models or small association studies with modest effect sizes. A consumer DNA test for CLOCK cannot provide a reliable estimate of your individual lifespan. Longevity is highly polygenic and heavily influenced by lifestyle, environment, and other genetic factors. Evidence grade: mechanistic/unclear. Relying solely on CLOCK for longevity guidance is not supported by current science.
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