Evidence check: FOXO3 in the context of Sport

The FOXO3 variant (e.g., rs2802292) is robustly associated with longevity in multiple studies, especially among centenarians. The evidence for longevity is human-strong (meta-analyses, replicated). In the context of sport, the data are sparse: FOXO3 regulates oxidative stress, autophagy, and muscle maintenance, which could theoretically influence recovery and muscle aging. However, current GWAS show only very small effects on endurance performance or recovery (effect sizes <0.1). There is no proven direct benefit for training prescription. The variant alone does not predict your athletic performance or injury risk. Training, nutrition, and sleep dominate. If you know your FOXO3 status, treat it as an interesting background factor, not an actionable directive. Supplements or specific training methods targeting FOXO3 lack evidence. Remain skeptical of exaggerated claims. Evidence: human-moderate (longevity strong, sport weak).