Myths vs facts: Ferritin Eisenmangel and Langlebigkeit

Myths vs facts about ferritin, iron deficiency, and longevity: Ferritin is the iron-storage protein and a key biomarker. Myth 1: 'Low ferritin always means iron deficiency.' Fact: Ferritin can be falsely low or normal during inflammation (acute-phase reaction); CRP should be measured concurrently. Myth 2: 'High ferritin is good for longevity.' Fact: Chronically elevated ferritin (iron overload) promotes oxidative stress and is linked to accelerated cellular aging, cardiovascular disease, and increased mortality. Myth 3: 'Iron deficiency is harmless as long as there is no anemia.' Fact: Functional iron deficiency (low ferritin with normal hemoglobin) can cause fatigue, cognitive impairment, and reduced physical performance. For longevity, a mid-range ferritin level appears optimal – neither too low (iron deficiency) nor too high (iron overload). Evidence comes from epidemiological studies and clinical observations, but large randomized trials directly targeting lifespan are lacking. Caveat: Ferritin values are individual and must be interpreted alongside inflammatory markers, liver function, and overall health. Self-testing without medical guidance can lead to misinterpretation.