Myths vs facts: CYP1A2 and stress

Claims linking CYP1A2 directly to stress are poorly supported by evidence. CYP1A2 is an enzyme primarily involved in caffeine and drug metabolism. Stress may modulate its activity via cortisol, but effects are variable and not robustly validated in human studies. Many direct-to-consumer tests overstate clinical utility. A DNA test alone cannot determine your stress response or guide stress management. Evidence: mechanistic/unclear. Caveat: marketing often exaggerates personalization.