What to watch with SHBG and weight loss?

SHBG (sex hormone-binding globulin) is a liver-produced protein that binds sex hormones. Weight loss, especially through improved insulin sensitivity, tends to increase SHBG levels. Low SHBG is associated with insulin resistance, fatty liver, and metabolic syndrome. However, SHBG is not a direct weight loss predictor. DNA tests claiming to guide diet based on SHBG gene variants have small effect sizes and limited clinical utility. The gold standard remains blood testing. If you are losing weight, focus on energy balance, protein, and exercise rather than single gene markers. Very low SHBG may warrant medical evaluation for underlying metabolic issues. Evidence: mechanistic; no strong nutrigenetic recommendation.