Is HLA-DQ2 useful for Fruchtbarkeit?

HLA-DQ2 is a genetic marker strongly associated with celiac disease. Untreated celiac disease can impair fertility due to malabsorption and chronic inflammation – affecting menstrual cycles, miscarriage risk, and sperm quality. However, HLA-DQ2 alone is neither diagnostic nor predictive of fertility. About 30% of the population carry this allele, yet only a minority develop celiac disease. Thus, a positive result may only prompt further celiac testing (antibodies, biopsy) in cases of unexplained infertility. Direct evidence for HLA-DQ2 as a fertility marker is lacking; studies focus on celiac patients, not on the general population. Consumer DNA tests often include this SNP, but interpretation requires clinical context. Without symptoms or risk factors, the test is not useful for fertility assessment. Evidence: human-moderate (celiac-fertility association, not HLA-DQ2 directly).