What role does Insulin play in Abnehmen?

Insulin is a key hormone in fat metabolism: it promotes glucose uptake into cells and inhibits lipolysis (fat breakdown). Chronically high insulin levels – caused by high sugar intake or insulin resistance – block fat release from adipose tissue, making weight loss harder. Conversely, low insulin levels (e.g., through fasting, low-carb diets, or exercise) favor fat burning. This physiology is well-established in evidence-based medicine. However, individual insulin sensitivity is partly influenced by genetics (e.g., TCF7L2 variants), but single variants have small effect sizes and do not justify rigid dietary prescriptions. Sustainable weight loss requires a holistic approach including energy balance, macronutrient composition, and lifestyle. Caveat: direct-to-consumer genetic tests often overclaim the predictive power of single markers.