What role does MC4R play in Langlebigkeit?

MC4R (melanocortin-4 receptor) is a key regulator of energy balance and appetite. GWAS have robustly linked variants (e.g., rs17782313) to obesity, a major risk factor for cardiovascular disease, diabetes, and reduced lifespan. However, the direct role of MC4R in longevity is indirect and moderate in evidence: it influences body weight and metabolic health, which in turn affect mortality. No strong studies show MC4R variants independently predict longevity beyond BMI. Consumer DNA tests often overstate the clinical impact. Lifestyle factors (diet, exercise) have a far greater effect on lifespan. Safety note: no direct risks, but avoid overinterpreting genetic results.