How are Homocystein and Langlebigkeit related?

Homocysteine is a sulfur-containing amino acid derived from methionine metabolism. Elevated homocysteine (hyperhomocysteinemia) is considered an independent risk factor for cardiovascular disease, stroke, and cognitive decline – all of which impact longevity. Evidence comes from large observational studies and meta-analyses (e.g., MTHFR C677T variants). However, randomized controlled trials show that lowering homocysteine with B vitamins (folate, B12, B6) does not consistently reduce cardiovascular events or all-cause mortality. Thus, homocysteine is now viewed more as a risk marker than a causal factor. Genetic variants such as MTHFR C677T and FUT2 rs601338 influence homocysteine and B12 levels. Elevated homocysteine should be interpreted alongside nutrient status, kidney function, and lifestyle. For evidence-based longevity, ensuring adequate B vitamins, a balanced diet, and regular exercise is more impactful than focusing solely on homocysteine levels.