Evidence check: Cortisol senken in the context of Sport

The question of whether sport can specifically lower cortisol is well-supported by general exercise physiology: moderate aerobic and resistance training consistently reduce basal cortisol and improve stress resilience. However, evidence for genotype-specific cortisol responses to exercise (e.g., variants in NR3C1, FKBP5, CRHR1) is limited and not yet clinically actionable. The provided context lacks direct studies on cortisol and sport genetics. Therefore, the evidence for personalized cortisol-lowering through sport based on DNA is 'unclear'. General recommendation: regular physical activity, especially endurance and mind-body exercises, effectively lowers cortisol regardless of genetic background. DNA tests for cortisol response in sports are not validated for routine use. Safety note: persistently high cortisol may indicate underlying medical conditions requiring professional evaluation.