Being identified as a poor metabolizer for CYP2D6, often due to variants like CYP2D6*4 (rs3892097), means your liver enzyme activity is significantly reduced. This slows the breakdown of many drugs, leading to higher blood levels and an increased risk of side effects. The evidence is strong (human-strong) and supported by CPIC guidelines. However, not all medications are affected; the impact depends on whether the drug is primarily metabolized by CYP2D6. Examples include certain antidepressants, antipsychotics, beta-blockers, and opioids. You should discuss your results with your doctor, who may adjust dosages or switch to alternative medications. Caveat: Other factors like liver function, co-medications, and lifestyle also influence drug response. A DNA test alone is not a substitute for medical advice.
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