Myths vs facts: VDR and longevity

VDR variants affect vitamin D utilization, not toxicity thresholds. Supplementing based solely on genetics is not recommended. Safe upper limits for children are 1,000–4,000 IU/day depending on age, but toxicity (hypercalcemia) can occur with high doses. Measure blood 25-OH-D levels before supplementing and consult a pediatrician. Evidence for genetically increased toxicity is lacking. Caveat: The test indicates a risk factor, not a diagnosis. Prioritize balanced diet and sun exposure.