How are BDNF and gut health related?

The relationship between BDNF (Brain-Derived Neurotrophic Factor) and gut health is a key topic in the gut-brain axis. BDNF supports neuroplasticity, learning, and mood regulation. The gut microbiota influences BDNF production via metabolites like short-chain fatty acids (e.g., butyrate) and by modulating inflammation. Animal studies consistently show that a healthy microbiome (e.g., through probiotics or fiber) increases hippocampal BDNF. Human observational studies suggest correlations between higher microbial diversity and BDNF levels, but causal evidence from randomized trials is lacking. Importantly, commercial microbiome tests (e.g., MyBody-X) do not measure BDNF directly; they profile bacteria. The evidence is moderate: strong mechanistic and animal data, but human clinical evidence remains limited. Consumers should be cautious about claims that a specific diet or supplement will boost BDNF based solely on a microbiome test. Always consult a healthcare professional before making significant dietary changes.