Evidence check: Fertility Check in the context of fertility

A DNA-based fertility check claims to identify genetic risk factors for reproductive challenges. However, the evidence is weak: most markers (e.g., MTHFR, FMR1, ESR1) show small effect sizes in GWAS and explain only a tiny fraction of fertility variance. Key determinants like age, hormone levels, lifestyle, and environmental factors are far more influential. These tests are not diagnostic and cannot replace clinical workups (hormone panels, ultrasound, semen analysis). Many panels lack independent validation. A positive result may cause unnecessary worry; a negative one may give false reassurance. Evidence: marketing. Safety note: Always consult a reproductive specialist before making decisions based on such tests.