Progesterone is a female sex hormone primarily secreted in the second half of the menstrual cycle. It can increase appetite and promote water retention, which may lead to slight weight gain rather than loss. While some studies suggest progesterone slightly raises basal metabolic rate, this effect is often offset by increased caloric intake. The relationship with weight loss is indirect: hormonal fluctuations can influence cravings, energy levels, and fluid balance, but no direct fat‑burning mechanism has been established. Evidence is based on observational studies and is moderate in strength. For sustainable weight loss, lifestyle factors (diet, exercise, sleep) are far more relevant than progesterone levels alone.
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