Can COMT help with sleep?

COMT (catechol-O-methyltransferase) is an enzyme involved in dopamine breakdown. The common Val158Met polymorphism affects enzyme activity: Val carriers degrade dopamine faster, which may be linked to lower stress resilience and potentially poorer sleep quality. Met/Met individuals have slower dopamine clearance, associated with higher anxiety and also possible sleep disturbances. Evidence is moderate, mostly from association studies. COMT testing alone is not sufficient to diagnose or treat sleep disorders. Sleep is influenced by many factors including stress, lifestyle, other genes (e.g., PER3, CLOCK), and environment. A MyBody-X DNA test can indicate genetic predispositions, but clinical relevance for individual sleep is limited. Results should not be used as medical diagnosis. For persistent sleep issues, consult a healthcare professional.