What role does VKORC1 play in Müdigkeit?

VKORC1 encodes an enzyme responsible for recycling vitamin K, which is crucial for blood clotting and bone metabolism. There is no established scientific evidence directly linking VKORC1 variants to fatigue. Clinically, VKORC1 is primarily used to guide warfarin dosing. While fatigue can be a side effect of warfarin, this is not a direct gene effect. Consumer DNA tests that claim VKORC1 predicts fatigue are overreaching. If you experience fatigue, consider medical evaluation for common causes like iron deficiency, thyroid issues, or sleep disorders. The evidence for VKORC1's role in fatigue is unclear.