How are VKORC1 and longevity related?

The relationship between VKORC1 and longevity is not well established. VKORC1 encodes an enzyme that recycles vitamin K, thereby influencing blood coagulation and bone metabolism. Some studies suggest that variants in VKORC1 may affect vitamin K status, which could theoretically impact vascular health and bone density—both factors linked to aging. However, the evidence is weak and mostly based on association or mechanistic reasoning. The MyBody-X DNA test can detect VKORC1 variants, but the clinical relevance for longevity is unclear. There are no robust longitudinal data showing a direct effect on lifespan. Additionally, interactions with medications (e.g., warfarin) must be considered. Without medical supervision, no supplements or therapies should be started solely based on this gene variant. The evidence is rated as 'unclear'.