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Home genetic tests, also known as direct-to-consumer (DTC) tests, analyze DNA from a saliva sample to provide information about ancestry, traits, or health risks. While some tests examine well-studied variants (e.g., MTHFR C677T), many rely on polygenic risk scores (PRS) that combine numerous small-effect variants. PRS have limited predictive power, especially across different ancestries, and are not diagnostic. DTC tests often overstate the significance of single SNPs; for example, MTHFR variants are frequently linked to autism risk despite weak evidence. These tests are not a substitute for medical diagnosis or professional genetic counseling. Results should be interpreted cautiously, considering lifestyle and family history. Privacy concerns also exist, as genetic data may be shared with third parties. In summary, home genetic tests can provide interesting insights, but their clinical utility is often limited, and they should not be the sole basis for health decisions.