Evidence check: Omega-3 Index in the context of longevity

The Omega-3 Index measures the percentage of EPA and DHA in red blood cell membranes and is considered a marker for cardiovascular health. A higher index (≥8%) is associated with lower risk of sudden cardiac death and favorable inflammation markers. However, direct evidence that raising the index extends lifespan is lacking from randomized controlled trials. Most evidence comes from observational studies linking higher Omega-3 Index to reduced all-cause mortality, but causality remains uncertain. Additionally, high doses (≥3 g/day) may affect blood clotting. For evidence-based assessment: the benefit for heart health is moderate, but a direct longevity effect is not proven. The index's value as a standalone longevity biomarker is limited. Be cautious of exaggerated marketing claims. Individual interpretation should involve a physician, especially if taking anticoagulants.