Evidence check: Progesteron in the context of gut health

Progesterone is a hormone primarily involved in the female menstrual cycle and pregnancy. It is known to slow gut motility, which can contribute to constipation or bloating. Some research suggests it may also influence the gut microbiome and intestinal barrier function, possibly through estrogen receptors or direct hormonal effects. However, the evidence linking progesterone to gut health in a clinically actionable way is still limited. Most data come from animal models or in vitro experiments, and human studies are sparse. Consumer DNA or microbiome tests, including those from MyBody-X, do not include validated progesterone-related markers for gut health assessment. If you suspect hormonal imbalances affecting digestion, consult a healthcare provider for proper hormone testing. Caveat: Progesterone supplements should only be taken under medical supervision due to potential side effects like thrombosis. Claims that a genetic test can predict progesterone's impact on gut health are not supported by current evidence.