warum nehme ich zu trotz kaloriendefizit — what does this mean exactly?

The question 'Why am I gaining weight despite a calorie deficit?' is not directly answered by the provided contexts. However, plausible mechanisms can be inferred from the DNA and microbiome hints: Genetic variants in genes like COMT (rs4680) or NR3C1 can affect stress metabolism and cortisol regulation, which may indirectly alter fat distribution or basal metabolic rate. Microbiome changes after antibiotics can impair energy extraction from food and short-chain fatty acid production, also influencing weight. Importantly, the effects of single variants are usually small, and a true calorie deficit physiologically leads to weight loss – if the scale still rises, common causes are water retention, hidden calories, medications, or metabolic adaptation. Consumer DNA tests are not medical diagnostics and cannot reliably explain weight changes. Persistent weight gain despite a documented deficit should be evaluated by a doctor to rule out thyroid, hormonal, or metabolic disorders.