Risks and limits of MTHFR Kinder

MTHFR child genetic tests (e.g., for rs1801133) are often marketed with claims about 'detoxification' or 'metabolism optimization.' However, the scientific evidence is weak: MTHFR variants are common (30–50 % of the population carry one) and usually have only minor effects on folate metabolism. A direct link to 'detoxification,' ADHD, autism, or other complex conditions is not established. For children, there is a lack of clinical validation studies for such direct-to-consumer tests. ISO certification ensures lab quality, not clinical relevance for the child. Risks include unnecessary parental anxiety, potentially inappropriate dietary changes or supplementation (e.g., high-dose methylfolate), and neglect of proper medical evaluation. An MTHFR finding alone does not justify treatment. A pediatric consultation is strongly advised before testing minors.