Evidence check: tTG IgA in the context of Wechseljahre

tTG IgA (tissue transglutaminase antibodies) is the standard screening test for celiac disease. During menopause, symptoms like fatigue, joint pain, bloating, and mood changes can overlap with celiac disease. However, there is no specific evidence that tTG IgA should be routinely tested in all menopausal women. Screening is only indicated when there are risk factors or suggestive symptoms. The test has high accuracy, but false positives can occur in other autoimmune conditions. The evidence for its use in the context of menopause is best described as practice-based, not strong clinical evidence. Caveat: A positive result should always be confirmed by duodenal biopsy.