Whether vitamin D (25-OH) can promote longevity is not yet conclusively established. Vitamin D is essential for bone health, immune function, and cell regulation. Some observational studies suggest an association between low 25-hydroxyvitamin D levels and increased all-cause mortality, especially in older adults. However, large randomized controlled trials demonstrating a causal effect on lifespan are lacking. Genetic factors (e.g., VDR variants) may influence vitamin D metabolism, but effect sizes are small and not deterministic. A DNA test for vitamin D-related genes is possible but has limited predictive value. A blood test for 25-OH vitamin D is useful to identify and correct deficiency. Supplementation beyond the recommended range has no proven benefit for longevity. Caveat: No single biomarker or genetic test can predict lifespan. A healthy lifestyle with adequate sun exposure, exercise, and balanced nutrition remains paramount.
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