Evidence check: TSH in the context of Langlebigkeit

TSH (thyroid-stimulating hormone) is a standard clinical marker for thyroid function. In the context of longevity, observational studies have noted that slightly elevated TSH (subclinical hypothyroidism) is more common among centenarians, possibly as a protective mechanism against oxidative stress or hypermetabolism. However, the evidence is largely associative, not causal. No interventional trials demonstrate that raising TSH extends lifespan. Moreover, untreated hypothyroidism carries cardiovascular and other risks. A blood TSH test reflects current thyroid status but does not directly measure longevity. Genetic variants affecting TSH (e.g., PDE8B, TSHR) have small predictive effects. Conclusion: TSH is a useful biomarker but not a standalone longevity indicator. Evidence is moderate, based on human observational data. Abnormal values require medical follow-up.