What role does CYP2D6 play in longevity?

CYP2D6 is a key enzyme in drug metabolism, but its direct role in longevity is not well established. Some studies suggest that certain variants may influence the metabolism of endogenous compounds like neurotransmitters or steroids, potentially affecting age-related diseases. However, the evidence is limited and often confounded by other genetic and environmental factors. The primary clinical use of CYP2D6 testing is in pharmacogenetics to guide drug dosing, not to predict lifespan. Consumers should interpret such results cautiously and consult a healthcare professional for personalized advice.