Evidence check: HLA-DQ2 in the context of weight loss

HLA-DQ2 is a genetic marker strongly associated with celiac disease. In the context of weight loss, a positive result may indicate undiagnosed gluten intolerance, which can affect weight through malabsorption or chronic inflammation. However, HLA-DQ2 alone is not a direct predictor of weight loss. Evidence for celiac risk assessment is moderate (many association studies), but for general weight loss it is weak and indirect. The test only provides a hint, not a diagnosis. For weight loss, it should only be used as part of a medical workup for celiac disease or gluten sensitivity. MyBody-X tests rely on marketing claims; the scientific strength for this specific link is 'moderate' (for celiac) to 'weak' (for weight loss).