How are CRP Entzündung and weight loss related?

C-reactive protein (CRP) is a key biomarker of systemic inflammation. Excess body fat, especially visceral adipose tissue, secretes pro-inflammatory cytokines such as IL-6, which stimulate hepatic CRP production. Weight loss—even a modest 5–10% reduction—consistently lowers CRP levels in clinical trials. Meta-analyses of randomized controlled trials report average CRP decreases of 0.5–2 mg/L following lifestyle interventions or bariatric surgery. The effect is dose-dependent: greater weight loss yields greater CRP reduction. However, CRP is non-specific; factors like acute infection, smoking, or chronic inflammatory diseases also elevate it. The clinical benefit of lowering CRP via weight loss is primarily a reduced cardiovascular risk. Caveats: a normal CRP does not rule out low-grade inflammation, and individual responses vary. Consumer tests that market CRP as a standalone predictor of weight-loss success or inflammation often overstate its utility. The evidence for the CRP–weight loss link is strong (human-strong), but interpretation requires a holistic clinical view.