What to watch with MTHFR and longevity?

MTHFR variants (C677T, A1298C) are common and affect folate metabolism and homocysteine levels. Elevated homocysteine is a risk factor for cardiovascular disease and cognitive decline – both relevant to longevity. However, the direct impact of single MTHFR variants on lifespan is small and inconsistent in large studies. Many consumer DNA tests overhype MTHFR, linking it to 'detox' or 'methylation' without solid evidence. A practical approach: measure blood homocysteine; if elevated, consider supplementing folate (preferably as 5-MTHF), B12, and B6 under medical guidance. Diet (leafy greens, legumes) remains the safest foundation. MyBody-X is a wellness test, not a diagnostic tool. Longevity is multifactorial – MTHFR is just one small piece.