Evidence check: Zöliakie Test in the context of gut health

A celiac disease test in the context of gut health is evidence-based, but reliability depends on the test type. Serological testing (tTG-IgA) is the gold standard with high sensitivity and specificity. Genetic testing for HLA-DQ2/DQ8 has strong negative predictive value: absence of these variants makes celiac disease extremely unlikely. However, a positive genetic test alone does not confirm active disease, as about 30% of the population carry risk alleles but only a minority develop celiac. In gut health contexts, genetic testing is useful for risk assessment, not diagnosis. For symptoms like bloating, diarrhea, or fatigue, medical workup with serology and duodenal biopsy is essential. Consumer DNA tests that analyze only single SNPs are insufficient for reliable celiac evaluation. Evidence for population screening without symptoms is weak. Caveat: a negative genetic test nearly rules out celiac; a positive test requires further investigation. No safety concerns, but avoid overinterpretation.