Is IgE useful for Wechseljahre?

The utility of IgE in menopause is not supported by strong evidence. IgE is primarily a marker for allergic reactions and parasitic infections. During menopause, hormonal shifts affect immune function, but there is no established clinical role for routine IgE testing in managing menopausal symptoms like hot flashes, mood changes, or sleep disturbances. Some mechanistic hypotheses suggest IgE might be involved in low-grade inflammation common in menopause, but human studies are limited and inconsistent. Current guidelines for menopause management do not include IgE measurement. If a woman has specific allergic symptoms (e.g., new-onset urticaria, rhinitis), IgE testing may be appropriate, but not as a general screening tool. Consumer tests offering IgE as part of a menopause panel should be viewed critically due to lack of validation. The evidence level is 'unclear'—no high-quality human trials or meta-analyses confirm clinical benefit. A more evidence-based approach includes hormone level assessment, vitamin D, thyroid function, and lifestyle factors. Over-reliance on IgE could lead to unnecessary interventions or false reassurance.