warum nehme ich nicht ab — what does this mean exactly?

The question 'Why am I not losing weight?' is one of the most common in health and genetic testing. It reflects frustration when diet or exercise fails to produce results. MyBody-X tests analyze SNPs like FTO (e.g., rs9939609) associated with higher BMI. Evidence comes from GWAS studies, but effect sizes are small (about 0.5 kg difference per risk allele). Other genes like MC4R or PPARG also play a role, but the influence is modest. Importantly, genetics explains only about 2–5 % of weight variation. Factors like calorie balance, sleep, stress, hormones (e.g., thyroid), and the microbiome are often more decisive. A genetic test cannot diagnose or prescribe a personalized diet. The question should not be taken as a reason to blame genetics alone, but as a prompt to take a holistic view of lifestyle and health. Caveat: marketing often overpromises; actual clinical relevance is limited.