What role does FADS1 play in Langlebigkeit?

FADS1 encodes a fatty acid desaturase crucial for converting short-chain omega-3 and omega-6 fatty acids into their long-chain forms (e.g., EPA, DHA). Variants like rs174547 are associated with altered blood lipid profiles and inflammatory markers. Since chronic inflammation is a hallmark of aging, FADS1 may influence longevity-related processes. However, evidence is moderate: mostly GWAS and observational studies linking variants to cardiovascular risk or cognitive decline. Direct lifespan extension is not proven. Diet (especially fish intake) can modify the genetic effect. Caveat: consumer genetic tests provide risk estimates, not diagnoses. Lifestyle and environment are far more impactful.