Evidence check: VKORC1 in the context of Fruchtbarkeit

The question about VKORC1 in the context of fertility is misleading. VKORC1 is a gene that influences sensitivity to the anticoagulant warfarin (e.g., Coumadin). It has no known direct link to fertility (egg maturation, sperm quality, implantation). The strong evidence for VKORC1 applies exclusively to pharmacogenetics: the gene variant (especially rs9923231) determines the required warfarin dose. During pregnancy, warfarin is teratogenic regardless of genotype. A 'normal' VKORC1 result therefore does not provide reassurance that warfarin is safe in pregnancy. Fertility itself is not affected by VKORC1. Anyone planning pregnancy while taking warfarin should discuss alternatives (e.g., heparin) with their doctor – independent of genetic testing. The evidence for a connection to fertility is absent; the strong evidence only applies to dosing. Consumers should not be misled by such genetic tests: VKORC1 is not a fertility gene.