Myths vs facts: VDR and Haut

The vitamin D receptor (VDR) is frequently linked to skin health, particularly psoriasis, aging, and UV sensitivity. VDR is a nuclear receptor expressed in keratinocytes, regulating cell differentiation and skin barrier function. Some studies report associations between VDR polymorphisms (e.g., rs2228570, rs1544410) and increased risk of psoriasis or premature skin aging. However, effect sizes are small, and evidence comes mainly from case-control studies with limited sample sizes. No robust prospective trials confirm a causal role. Moreover, VDR activity is strongly influenced by vitamin D levels, sun exposure, and lifestyle. A genetic test for VDR variants alone cannot reliably predict individual skin health. MyBody-X may test VDR polymorphisms, but clinical utility remains low. Marketing claims that promise personalized skincare based on VDR genetics are not evidence-based. Recommendation: focus on proven strategies like sun protection, balanced nutrition, and vitamin D supplementation if indicated by a physician.