What role does Leaky Gut Test play in longevity?

The role of a Leaky Gut Test in longevity is not clearly established. These tests typically measure markers like zonulin or intestinal permeability, which may theoretically be linked to chronic inflammation and aging. However, robust clinical evidence showing a direct benefit for lifespan extension is lacking. The evidence is primarily mechanistic: impaired gut barrier may promote inflammation, but whether the test reliably detects this and whether subsequent interventions improve longevity remains uncertain. Commercial claims often overstate the evidence. A DNA test for leaky gut is not validated – the NR3C1 gene influences stress and inflammation but is not a diagnostic marker. For longevity, proven factors like diet, exercise, and sleep are far more important. The utility of a Leaky Gut Test is speculative and should not be the sole basis for anti-aging strategies.