How are hsCRP and longevity related?

hsCRP (high-sensitivity C-reactive protein) is an inflammatory marker. Chronically elevated levels (≥2–3 mg/L) are associated in epidemiological studies with increased risk of cardiovascular disease, frailty, and premature mortality – thus shorter lifespan. However, hsCRP is not a direct 'longevity marker' but rather an indicator of systemic inflammation, which can accelerate aging. Evidence comes from large observational studies (e.g., JUPITER trial) and meta-analyses showing a moderate, independent association. Causality is not firmly established, as hsCRP may be a bystander of other risk factors. A low hsCRP (<1 mg/L) is considered favorable, but lifestyle factors (diet, exercise, smoking cessation) influence hsCRP more than genetic tests. Consumer DNA tests for hsCRP have limited predictive power. Bottom line: hsCRP is a useful but non-definitive biomarker for inflammation-related health risks. Evidence: human-moderate.