Is Folsäure useful for longevity?

Whether folic acid (folate) is useful for longevity is not clearly supported by evidence. Folate is essential for DNA synthesis, repair, and methylation – processes central to cellular aging. Observational studies link adequate folate status with lower risks of cardiovascular disease, cognitive decline, and some cancers. However, no robust randomized controlled trial demonstrates that folic acid supplementation extends lifespan in healthy individuals. In fact, high doses of synthetic folic acid (>1 mg/day) can mask vitamin B12 deficiency in older adults and may even promote certain cancers. For most people without a diagnosed deficiency, extra folic acid likely offers no measurable longevity benefit. Genetic tests (e.g., MTHFR) do not provide clinically actionable guidance for supplementation. The evidence is primarily mechanistic and observational; strong human trials are lacking. Practical takeaway: ensure adequate folate from whole foods (leafy greens, legumes) rather than relying on high-dose supplements for anti-aging purposes.