What do studies say about Longevity Männer?

Evidence on longevity in men is mixed and often limited. Some genetic variants (e.g., APOC3 promoter SNPs linked to triglycerides/insulin resistance, ACTN3 R577X for power performance) have been studied, but their individual impact on lifespan is small. NMN supplements are promoted for longevity but lack human RCTs; the FDA has questioned their supplement status. BDNF Val66met shows weak associations with glucose metabolism. Most claims rely on mechanistic or animal data. Lifestyle factors (diet, exercise, sleep) remain the only evidence-based strategies. Be cautious of overhyped biohacker interventions.