Myths vs facts: MTHFR and Fruchtbarkeit

Myths vs facts: MTHFR and fertility. The myth claims that MTHFR variants (C677T, A1298C) impair fertility and require special methylfolate supplementation. The facts: ACMG/CDC do not recommend MTHFR screening because the variants do not clinically impair folic acid metabolism. Studies on MTHFR and fertility show conflicting results – some associations with recurrent pregnancy loss, but no causal evidence. Blood homocysteine measurement is more informative than a genetic test. Methylfolate is unnecessary and may mask B12 deficiency. For fertility, lifestyle, nutrition, and medical evaluation matter more than an MTHFR genotype. Evidence is moderate; most guidelines advise against routine testing.