The relationship between lowering cortisol and longevity is not directly proven, but there is plausible mechanistic evidence. Chronically elevated cortisol – often from long-term stress – is linked to accelerated aging, impaired immune function, insulin resistance, and increased cardiovascular risk. Therefore, reducing persistently high cortisol may indirectly support healthy aging and longevity by mitigating these harmful effects. Magnesium supplementation, for example, can modestly lower cortisol in deficient individuals, but the effect is small and not guaranteed. However, no large-scale human trials have directly shown that lowering cortisol extends lifespan. The evidence is primarily mechanistic and observational. A holistic approach including stress management, sleep optimization, and a balanced diet is more robust than targeting cortisol alone. Caveat: a single high reading is often temporary; multiple tests and clinical correlation are needed. Home tests cannot diagnose Cushing's syndrome or other endocrine disorders.
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