What role does Testosteron play in allergy?

The role of testosterone in allergy is not well established. Observational and mechanistic studies suggest that testosterone may modulate immune responses, potentially suppressing Th2-driven allergic inflammation. Men generally have lower IgE levels and a lower prevalence of asthma and hay fever compared to women, hinting at a sex-specific effect. However, the effect size is small, confounded by other hormones (estrogen, progesterone), and not supported by robust interventional trials. No direct evidence from randomized controlled trials exists showing that testosterone supplementation alters allergy outcomes. Consumer DNA tests do not include validated markers for testosterone–allergy interactions. In summary, testosterone likely plays a minor, modulatory role in allergy, but current evidence is insufficient for clinical or dietary recommendations. Evidence: mechanistic/observational, not actionable.