Myths vs facts: BDNF and Haut

BDNF (Brain-Derived Neurotrophic Factor) is best known for its role in the brain, but it is also expressed in skin cells. Myth: BDNF only matters for the nervous system. Fact: BDNF is produced by keratinocytes, melanocytes, and fibroblasts, influencing wound healing, pigmentation, and skin aging. Studies suggest altered BDNF levels in psoriasis and atopic dermatitis. However, evidence remains largely mechanistic; direct clinical recommendations for skincare or supplements are not well-supported. A DNA test for BDNF variants (e.g., rs6265) may offer clues about individual differences, but effect sizes are small and lifestyle factors dominate. Be cautious of marketing claims that label BDNF as an 'anti-aging miracle'.